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( F and G ) Plots showing the relative abundance of major TCA cycle metabolites at 6 circadian time points ( F ) or at ZT16 ( G ) in kidneys of Ctrl and cKOt mice

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Autophagy 13 , 15121527 (2017)

When the cell senses oxidative stress, Nrf2 responds by translocating from the cytoplasm to the nucleus, where it binds to the antioxidant-response elements located in the promoter regions of genes responsible for antioxidant production [68, 69]

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The mean values of serum lipid peroxidase were increased and superoxide dismutase and glutathione peroxidase levels were decreased in type II Diabetes mellitus as compared to controls