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Potential considerations include: Gastrointestinal sensitivity during therapy initiation

Providing complete information and proper education to patients with diabetes can dramatically increase adherence to the treatment regimen

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Functional enrichment was assessed using Fishers exact test on differentially expressed proteins (DEPs)

The challenge often comes several weeks or months later when progress slows or life becomes busy

Patients should respond promptly to defecation urges rather than delaying, as postponement can lead to progressive stool hardening and more difficult evacuation