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While enhanced alcohol metabolism may seem protective, elevated CYP2E1 accelerates ethanol oxidation, resulting in higher acetaldehyde production and excessive reactive oxygen species (ROS) generation, including hydroxyethyl radicals, superoxide anions, and hydroxyl radicals [27, 28]

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Bergapten: a review of its pharmacology, pharmacokinetics, and toxicity

Activation of these neurons drove T cells to home to the bone marrow via a CXCR4/CXCL12 axis-dependent mechanism, possibly mediated by a neural circuit stimulating corticosterone secretion