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This is the result of a deficiency that remains untreated over a long period

It does not have the evidence to be called a weight-loss product on its own

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This work suggests that we may have overlooked a third phase, perhaps the most challenging one: maintaining the result over the long term

[1] [12] For most people, doses up to 2 mg (2000 micrograms) daily are unlikely to cause harm according to NHS guidance, as B12 is water-soluble and excess is typically excreted in urine

These approaches constrain confounding and selection bias during the design phase rather than relying on post hoc statistical corrections