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In detail, GLP-1 treatment leads to a decrease in M1 markers, including IL-6, TNF-, and inducible NOS ( i NOS), while promoting increased levels of markers of M2 such as IL-10, arginase-1(Arg-1), macrophage galectin-1 (MGL-1), and mannose receptor-1 (MRC-1) in murine RAW264.7 macrophages [14, 79]

More recent meta-analyses confirm that digital self-monitoring, delivered via apps, wearables, or electronic scales, produces moderate weight loss and improves adherence compared to paper-based approaches, with higher engagement linked to greater weight reduction [91, 92]

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Association between vitamin D and knee osteoarthritis in Indian population: a systematic review and meta-analysis