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Interestingly, higher incidence of diabetic retinopathy (DR) complications was noted in patients taking semaglutide (3.0%) compared to placebo (1.5%) in clinical trials, with greater risk in those with a history of DR [32]

The incidence, disability rate and mortality rate of cancer have been increasing, and cancer has become one of the main threats to human health ( 2 GLP-1R and its function Glucagon-like peptide-1 (GLP-1), which is mainly secreted by L cells in the colon and distal small intestine, is a newly discovered glucagon-like peptide-1 that can promote insulin secretion and lower the blood sugar peak more effectively than previously reported ( Therefore, GLP-1 has become an important target for glucose homeostasis regulation

Collagen supplementation, particularly combined with resistance training and adequate protein, helps protect muscle mass during GLP-1 weight loss

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Dermatologists in practice have also noted glutathiones benefit as a supporting treatment for hyperpigmentation

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