A B12 injection is a highly effective way to get this vitamin right where it needs to go, bypassing the digestive system for maximum absorption
The only significant change was a 6% decrease in platelet count (p = 0.02)
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Other notable adverse effects include: Injection site reactions such as erythema, pruritus, or swelling Fatigue reported in approximately 5% to 6% of patients Hypoglycemia when used in combination with insulin or sulfonylureas Increased heart rate with modest elevations of 2 to 4 beats per minute (a class effect of incretin therapies with uncertain clinical significance) Serious but rare adverse effects include acute pancreatitis, gallbladder disease (cholelithiasis, cholecystitis), acute kidney injury (typically secondary to dehydration from gastrointestinal symptoms), and hypersensitivity reactions
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Vitamin B12 functions as a cofactor for two essential enzymes: methionine synthase (involved in homocysteine metabolism and DNA synthesis) and methylmalonyl-CoA mutase (crucial for fatty acid and amino acid metabolism)
