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Environmental factors, like UV rays and pollution, can speed up aging
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Accordingly, mice with liver-specific IGF-I deficiency, instead of displaying decreased hepatic growth, showed disproportionally large livers, likely due to direct stimulation by an unsuppressed GH secretion[47, 93]
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FoxO1 target Gpr17 activates AgRP neurons to regulate food intake
Buchwald H, Estok R, Fahrbach K, Banel D, Jensen MD, Pories WJ, Bantle JP, Sledge I
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