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Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling

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10.3389/fphar.2017.00904 Front

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The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE 102 partner repository with the dataset identifier PXD039403 and 10.6019/PXD039403 ( References Linder, P