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ectopic fat deposition in the liver and epicardium triggers inflammation, disrupts myocardial energy metabolism, and promotes fibrosis, contributing to cardiac dysfunction and diastolic impairment

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Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy, [see WARNINGS], reserve opioid analgesics, including hydrocodone bitartrate and acetaminophen tablets, for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain

Tirzepatide is administered once weekly on the same day each week and can be taken any time of day, with or without food