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In a real-world retrospective observational cohort of more than 140,000 patients with T2D, tirzepatide was associated with greater 0.34 percentage point reduction in glycated hemoglobin A1c (HbA1c), 2.9 kg body weight reduction, in addition to lower rates of all-cause mortality (HR 0.58, 95% CI 0.450.75), MACE (HR 0.80, 95% CI 0.710.91), and major adverse kidney events (HR 0.54, 95% CI 0.440.67) compared with GLP-1RAs [28]
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If the results hold, Eli Lilly would likely move toward FDA submission, with approval potentially following in 20262027
If youre not losing weight, talk to your doctor about dose adjustments, dietary changes, or additional strategies to support your treatment goals
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