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GHK-Cu's copper complex can be destabilized by very low pH and by direct oxidizing or reducing agents

Prognostic significance of P21waf1/Cip1, P27kip1, P53 and e-cadherin expression in gastric cancer

May 2021;35(5):2386-2395

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This condition is temporary and often resolves within a few months

On the downside, the biological role of LMW-HA in the skin is being a pro-inflammatory signaling agent and there is a study by another manufacturer called Evonik showing that HA versions with smaller than 50kDa molecular weight might be pro-inflammatory when put on the skin