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Simultaneously, novel therapeutic targets and innovative approaches continue to be developed for clinical translation

15 proposed that deprotonation of Cys497 TrxR occurs either through direct proton transfer from Cys497 TrxR to Cys35 Trx or via solvent water molecules

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Liposomal glutathione takes this same active nutrient and encapsulates it within fatty vesicles called liposomes

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Furthermore, NADPH pools are compartmentalized in various organelles with no known membrane transporters, suggesting that NADPH-dependent pathways are regulated in an organelle-specific manner