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GIP receptor activation appears to influence adipose-tissue metabolism and insulin sensitivity in ways that may complement GLP-1s appetite and glycaemic effects

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"Most importantly, have regular eye tests with your optometrist or ophthalmologist whilst you're being treated and letting them know that you're taking these medications." Professor Garron Dodd, head of the Metabolic Neuroscience Laboratory at the University of Melbourne, thinks there is still a question mark over whether the GLP-1 based drugs actually cause NAION considering most people taking the drug already have known risk factors

But the relationship between weight loss and fertility is actually more positive than you might think