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Diabetes Care , 41 (10), 2063-2071

Warning signs include decreased urination, dark urine, dry mouth, dizziness upon standing, rapid heart rate, or persistent fatigue

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Discontinuation Rates Were Higher Than Expected Patients stopped treatment because of side effects at the following rates: 18.2% on the highest dose 12.2% on the 9 mg dose 4% on placebo By comparison: Zepbounds/Mounjaros discontinuation rate was 6.2% Retatrutides Phase 2 discontinuation reached 16% This suggests that while retatrutide produces massive weight loss, it may also present more difficulty for some patients