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placebo), symptom severity categories, and their interaction (Table 4)

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In this respect, it is interesting that thrombin injected into the ear skin of mice produced a dose dependent degranulation of mast cells and the mast cells expressed thrombin receptors PARs 1, 3 and 4 [98]

Ethics declarations Ethics approval and consent to participate This study was conducted in compliance with the ethical principles of the Declaration of Helsinki

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This suggests a need for more rigorous research to validate the efficacy and safety of AOMs in this demographic