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NPs fabricated by different materials differ in the mechanisms of toxicity
Both utilized antibiotic depletion (ABX) to diminish the microecological background, verified therapeutic transferability via fecal microbiota transplantation (FMT), and further achieved partial simulation or restoration of therapeutic phenotypes through butyrate/sodium butyrate supplementation (rescue) ( Level B Support: In the CFA-induced RA rat experiment, the study found that after antibiotic (ABX) treatment, the improvement effect of JFG on foot swelling, synovial lesions and inflammatory factors was significantly weakened
NAC is not necessarily better than glutathione for detoxification, but it works differently
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