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Provides comfort support and does not replace medical pain management

Severe allodynia that significantly impairs daily function may warrant dose reduction or temporary discontinuation

Increased risk of mortality was also seen in patients with IBS-D taking diphenoxylate/atropine (HR = 1.89), which is a combined mu and muscarinic receptor agonist 41

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Funding This work was supported by the Scientific Research Project Coordinator of Selcuk University [grant number 23401109] and The Scientific and Technological Research Council of Trkiye [grant number 124O204]

A comprehensive examination of the included papers was undertaken to ascertain any other pertinent research that could be incorporated into the evaluation (Figure 7)