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In murine models of inflammatory arthritis, liraglutide treatment significantly reduced synovial inflammation, joint damage, and the expression of cytokines such as TNF- and IL-1, likely mediated through GLP-1R expressed on macrophages and fibroblast-like synoviocytes within the inflamed joint microenvironment [368370]

Stelara (ustekinumab) Disease area(s): Immunology Manufacturer(s): Johnson & Johnson 2024 Sales (USD): $10.36 billion Why it sold so well: J&Js immunology blockbuster Stelara generated approximately $10.36 billion in global sales in 2024, a 4.6% decline from the previous year

doi: 10.1016/j.jacc.2020.05.037 38 DaviesMJDAlessioDAFradkinJKernanWNMathieuCMingroneGet al

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Learning proper injection technique, site rotation, and pre-injection preparation can dramatically lower your risk of visible marks and discomfort

Monthly follow-up visits with the same provider