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Our earlier preview of the seven peptides under FDA review explains what each compound does and why it was nominated.

J Biol Chem 267:74027405 Erickson MA, Banks WA (2013) Bloodbrain barrier dysfunction as a cause and consequence of Alzheimers disease

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Collectively, these findings suggest, in vitro , that ZIP8 may contribute to both uptake and efflux of Mn, while ZIP14 may play a greater role in Mn efflux due to its basolateral enrichment and specific impact on basolateral-to-apical transport

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