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Additionally, findings from a recent study indicate that high doses of PPR may lead to cardiac adverse effects in rat (unpublished data), further complicating its safety profile

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In patients who have had gastric bypass surgery, most of the stomach is bypassed, limiting the breakdown of vitamin B12 and its absorption.

Such a swinging arm is rare for an unstructured element in enzymatic catalysis, and the molecular shuttle in CstB appears to be more functionally complex as it integrates oxidative and persulfide transferase activities in a highly concerted fashion