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Standard error of the mean SNc Substantia nigra pars compacta SLE Systemic lupus erythematosus STZ Streptozotocin SORT Selective organ targeting SSTR2 Somatostatin receptor 2 T2DM Type 2 diabetes mellitus T1DM Type 1 diabetes mellitus TEM Transmission electron microscopy TH Tyrosine hydroxylase TNBS Trinitrobenzene sulfonic acid UUO Unilateral ureteral obstruction UCP1 Uncoupling protein 1 USPIO Ultrasmall superparamagnetic iron oxide UTMD Ultrasound-targeted microbubble destruction WAT White adipose tissue WD Western diet ZnO NPs Zinc oxide nanoparticles ZDF rats Zucker diabetic fatty rats Author contributions Juan Zeng: Writing original draft

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