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Description

The Peptide InnOvatioN for Early diabEtes tReatment (PIONEER) phase 3 programme demonstrated the efficacy of oral semaglutide versus placebo and active comparators (including empagliflozin, sitagliptin and liraglutide) in achieving glycaemic control and weight loss, with a safety profile consistent with the GLP-1RA drug class [10,11,12,13,14,15,16,17,18,19,20,21]

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Initially developed as glucose-lowering therapies, both classes have shown impressive cardiovascular and kidney-protective effects [17,18]

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This form is often compared to other injectable medications like insulin glargine and empagliflozin in studies

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The tissue homogenates were stored at 70 C until analysis

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