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Acknowledgements This work was supported by grants from the National multidisciplinary collaborative diagnosis and treatment capacity building project for major diseases (TJZ202104), the Natural Science Foundation of China (82270643, 82070644, 82170621 and 82370645), the Science and Technology Major Program of Sichuan Province (2022ZDZX0019), the Sichuan Science and Technology Program (2024NSFSC0645), 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18008, ZYGD22006)

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19.1 Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S 1999 Thymus and Autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T Cells as a key function of the thymus in maintaining immunologic self-tolerance