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Karagounis TK, Cohen DE
104 , 898S901S (2016)
Weight loss on peptide therapy is not linear, and temporary stalls of 1-3 weeks are normal even on optimal protocols
As dual and multi-receptor agonists (e.g., targeting both GLP-1 and GIP receptors) become more prevalent, purification workflows must adapt to the increased complexity of peptide structures
It suggests the drug reached the brain and affected disease-relevant pathways, but that timing, magnitude, delivery, or patient selection were insufficient to overcome established neurodegeneration when used as a stand-alone therapy
A rat polyclonal antibody localized using immunohistochemistry the GLP-2R to vagal afferents, enteric neurons, enteroendocrine cells, and myenteric plexus nerve fibrils (Nelson et al., 2007)
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