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One-carbon metabolism refers to biochemical pathways involving the transfer of single carbon units and is critical for the synthesis of proteins and nucleotides, amino acid homeostasis, and epigenetic control of DNA expression

The researchers showed that Retatrutide can reverse this process

Half an hour before the end of the incubation with the indicated stimulus, Hoechst was added to each well of 24-well plates at a final concentration of 1 M

10.3390/cells13020116 87 LeppertD.WaubantE.GalardyR.BunnettN

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