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& Hoffman-Kim, D

These gastrointestinal effects are typically most pronounced during the first four to eight weeks and diminish with continued use

Subsequently, patients are advised to escalate their intake by increasing the dosage to a daily measurement of 7 mg3

Other chemical agents, such as those used in laboratories and industries, natural chemicals (e.g., alpha-amanitin), and herbal remedies (two prominent examples being kava, though the causal mechanism is unknown, and comfrey, through pyrrolizidine alkaloid content) can also induce hepatotoxicity

NOTE: People have mixed reactions to copper peptides

doi: 10.3390/foods13223656 18