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The observed effects were consistent in all investigated subgroups, with a trend toward stronger effects in subjects with T2D and higher cardiovascular risk (77)

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Activation leads to: Increased sebum production , may contribute to acne in some research subjects Changes in sebum composition Pheromone secretion (in animal models) This is a less important mechanism with Melanotan II, but contributes to its non-selective profile

Monitoring requires baseline and ongoing liver function tests, FIB-4 scoring for fibrosis risk, and vigilance for pancreatitis and gallbladder disease

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