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The importance of this hinge region was confirmed by the synthesis and utilization of a hexapeptide mimic (Hinge: KDYIRN) that bound to HGF with high affinity and blocked HGF dimerization [38]

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doi: 10.1038/nature05485 157 CuratCAMiranvilleASengensCDiehlMTonusCBusseRet al

In rare cases, especially at high doses or with misuse, stimulants can contribute to severe symptoms such as paranoia or psychosis