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The neurological consequences of untreated B12 deficiency can be serious and potentially permanent, including subacute combined degeneration of the spinal cord, which affects both sensory and motor pathways
But with the extra receptors in the neuron connections (synaptic cleft), over-firing occurs
For example, a 1,000 mcg dose might be in 1 mL of solution, but this can vary with different formulations
If blood tests show clearly low levels (thresholds vary by lab, but often below roughly 200 pg/mL) or there are signs of anemia, a provider may recommend weekly injections for the first several weeks as a correction or "rescue" phase
By delivering vitamin B12 directly into the bloodstream, injections bypass the digestive system, ensuring optimal absorption and faster benefits
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