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Regulation of glucose homeostasis by GLP-1

Preparation of KA-Induced Seizure Model Male C57BL/6J mice (68 weeks of age, weighing 1822 g) were obtained from the Animal Unit of Central South University

In white adipose tissue of obese, insulin-resistant and aged mammals, NNMT is dramatically upregulated and because it consumes both the universal methyl donor (SAM) and the NAD precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve and the NAD-salvage pool [1,2]

thaliana seedlings co-cultivated with the root-colonizing endophytic fungus Piriformospora indica suggesting an important role of the enzyme in the maintenance of mutualistic plant- fungal interaction (Vadassery et al., 2009)

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