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In particular, key gaps persist regarding the primary target tissues and potential tissue-biased signaling, the largely unexplored role of BAT, the integration of GIPR- and GLP-1R-mediated downstream pathways, and the mechanisms underlying their anti-inflammatory effects and inter-organ crosstalk

Here in this pre-specified analysis, we examined effects of semaglutide on weight and anthropometric outcomes, safety and tolerability by baseline body mass index (BMI)

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