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The ROS disrupt essential cellular processes by interacting with DNA, RNA, and protein synthesis, which may result in inflammation, cell necrosis, or apoptosis 14
108 published a study about the beneficial effect of melatonin in the treatment of neonatal sepsis that involved 40 septic neonates and concluded that the group who received melatonin had a significant improvement in clinical condition and serum parameters compared with the control group
PMID: 52 MeinsohnM-CSmithOEBertolinKMurphyBD
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(2025), astrocytes gene signatures are upregulated during the early symptomatic stage, characterized by proliferation, and subsequently they decline as pro-inflammatory genes become upregulated during disease progression in TDP-43 mouse model
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