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, diabetes, dysbiosis), chemical reactivity enables spontaneous modification, potentiated by glyoxalase system dysregulation: methylglyoxal is converted by glyoxalase 1 (GLO1) to lactoylglutathione (LGSH), which undergoes non-enzymatic acyl transfer to lysine residues ( Cellular lactate concentration directly modulates Kla levels (glycolytic inhibition suppresses Kla, while mitochondrial dysfunction or hypoxia enhances it) ( Figure 1 )

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