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or Have intolerable adverse effects associated with allopurinol treatment requiring treatment discontinuation and have trialled probenecid at doses up to 2 g per day or to a maximum tolerated dose

Cloudiness can indicate aggregation, contamination, or temperature damage

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Lower NAD+ means reduced sirtuin activity (SIRT1, SIRT3), which further impairs mitochondrial function and fatty acid oxidation in fat cells