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10.1002/ptr.6100 202 TakekoshiS.NagataH.KitataniK

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Clinically Relevant Experimental Animal Models Because of the limitations/difficulties related to human studies due to in part to ethical concerns, the use of experimental animal models becomes an important alternative to investigate disease pathogenesis

provided evidence of B cell ferroptosis in SLE patients and SLE mouse models, suggesting that ferroptosis may regulate B cell differentiation and plasma cell formation, thereby implicating this process in SLE pathogenesis [102]

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