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Summary G6PD deficiency is the most common genetic enzyme disorder

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The key distinction is that normal reactions are localized to the immediate injection areathey do not spread, worsen after 24 hours, or cause systemic symptoms like fever or chills

however, this bleed surprisingly spontaneously resolved within 48 h with no clinical effect, which is very atypical for the natural history of this devastating disease where recurrent bleeds tend to become more severe