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274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

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Meet Glutathione Often called the master antioxidant, glutathione is a small protein composed of three amino acids (cysteine, glycine, and glutamic acid) and a sulfur group

In-vivo efficacy and safety data in human subjects remain unavailable

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[22] GSH is a highly important indirect antioxidant by acting as a coenzyme for various enzymes that couple GSH-to-GSSG oxidation to the reduction of harmful oxidizing species