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Significant negative symptoms were found in the active treatment group compared to controls but not in positive or general psychopathology [6]
73 In summary, peripheral administration of GLP-1RAs either acts directly on the hypothalamus and hindbrain, which lack BBB, or directly crosses the BBB into CNS, which are then projected to other key feeding areas of the brain (Figure 6)
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However, there is evidence of FAO in astrocytes derived from rat brain and expression of FAO enzymes in other parts of the rat brain as well as in neural cells from human fetuses [13,14,15]
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