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Obesity is characterized by a body mass index (BMI) greater than 30 kg/m 2 , and it has rapidly become a global disease, with over four million deaths each year ( Figure 1 )

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Placebo-Controlled Studies With DPP-4 Inhibition as Monotherapy In drug-nave subjects with type 2 diabetes who were treated with diet and life style, the DPP-4 inhibitors were examined as monotherapy in placebo-controlled 2426 week studies with a total number of 2,328 subjects [Table 2