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The strategy employed has been to link GLP-1 or glucagon receptor agonists to nuclear hormones such as oestrogens, thyroid hormones and dexamethasone (reviewed in [64, 96, 99])

This paradigm, established through twentieth-century techniques like classical histology, biochemistry and electron microscopy, presumed morphological similarity and uniform functional responses to stimuli among -cells (Zhu et al., 2017)

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The cardiovascular phenomenon of endothelial dysfunction involves a series of structural and functional abnormalities, including abnormal secretory capacity and properties of the endothelium and impaired vascular tone, as well as an impaired endothelial barrier function

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