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Additionally, exendin-4 treatment increases c-fos expression in in GLP-1R+ Paneth cells (Figure 1), which is abolished when exendin-(939) is administered prior to exendin-4 treatment (Kedees et al., 2013)

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It takes six to seven weeks of weekly shots before the body reaches steady levels of exenatide

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However, some patients report leg discomfort anecdotally