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doi:10.1152/japplphysiol.00945.2010 Sikiric P, Blagaic AB, Strbe S, et al

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Farm animals are often supplemented with cobalamin in their feed

In esophageal injury models, BPC-157 normalizes sphincter function by increasing pressure in both the lower esophageal sphincter (LES) and pyloric sphincter (PS) in animals with sphincter dysfunction, while in healthy animals the peptide demonstrates adaptive effects that maintain physiological sphincter tone

The peptide acts as a competitive inhibitor of this interaction, enabling investigation of transcriptional regulation, cellular senescence pathways, and stress-response signalling