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GLP-1R activation leads to an increase of intracellular cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) and phosphoinositide 3-kinase (PI3K) with a subsequent activation of some downstream signaling pathways associated with cell survival [42]

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Sleep disturbances are in fact common in many mouse models (Drew et al., 2023

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They are most effective for mild constipation