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The primary contribution to the barrier function belongs to the BBB since at the level of brain micro-vessel endothelium BBB is the major site of blood-CNS exchange (Zenaro et al., 2017)

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Pfizer scrapped a different once-daily obesity pill back in June 2023 after patients who took that drug had higher liver enzyme levels in a mid-stage trial

While many of the side effects are common and mild, such as nausea, vomiting, and diarrhea, some are more severe resulting in long-term health problems

2022;23(1): e9344