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Cardiovascular Outcome Trials in Type 2 Diabetes CVOTs in T2D were designed primarily to establish cardiovascular safety in patients diagnosed with T2D who also have established cardiovascular disease (CVD) or have a high cardiovascular risk

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Compound pharmacies, Telemeds, and diet companies like Weight Watchers and Noom promote cheaper, non-FDA-approved versions without studies, hiding serious risks, high failure rates, and dependencywithout doctor oversight

This may help explain why increased PQQ is associated with improved measures of cognition and learning in aging humans and rats [30]

1993 Aug;138(2):327-36