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The good news is that MOTS-C and Retatrutide have very different side effect profiles with minimal overlap, which keeps the combined risk manageable

Mun, Y., Kim, W., & Shin, D

We probably need to think of these drugs in the context of multiple disease treatment in tandem with obesity, such as those with metabolic syndrome, CVD, CKD, and MASLD

This approach extends the ramp-up period significantly but can dramatically reduce the GI side effects that cause many patients to abandon treatment early

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In fact, after completing your treatment, most people notice a 50-70% improvement