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found that reduced CSF PLP concentrations may be a more sensitive indicator of vitamin B6-dependent epilepsy, especially vitamin B6-dependent epilepsy caused by mutations in PLPBP [12]

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Disabling low back pain and depressive symptoms in the community-dwelling elderly: a prospective study

Quality-of-life scores improved, likely driven by weight loss and metabolic benefits but possibly also through direct central nervous system effects (GLP-1 receptors exist in mood-regulating brain regions)

It also increases the risk for a patient to have complications of sedation such as aspiration

References Foundational telomerase/telomere research Khavinson VK, Bondarev IE, Butyugov AA