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In humans, kidney removes 68 U of insulin per day by two major routes (Figure 2), that apparently have distinct preferential physiological goals: post-glomerular secretion (insulin signaling) and glomerular filtration (nutrient conservation and homeostasis) (Ritz et al., 2013)

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doi: 10.1038/s41598-019-51343-1 163 MoritaMKanasakiK

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The major action of nicotinic acid in this capacity is a reduction in fatty acid mobilization from adipose tissue

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