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The second internal factor that leads to bright skin is good circulation

Deckel and Duffy 2000)

doi:10.1038/s41591-022-02026-4

It is this dynamic that has made measurement of serum ceruloplasmin the primary screening test for Wilsons.16 Ultimately, the excess retained copper in the hepatocytes of Wilsons patients leads to toxic injury to the cell and eventually spillage of copper into the circulation, where it may be deposited in other organs such as the brain, cornea, and kidneys

Sugatani J, Noguchi Y, Hattori Y, Yamaguchi M, Yamazaki Y, Ikari A (2016) Threonine-408 regulates the stability of human pregnane X receptor through its phosphorylation and the CHIP/chaperone-autophagy pathway